Of the side effects immunotherapy can cause, skin reactions are one of the most common. They occur because the activated immune system mistakenly attacks healthy skin cells.
“These reactions can include rashes, itchiness, redness, dryness, and in some cases, blisters or sores,” Alter notes. The rash often appears on the face and upper body, and some people describe it as feeling similar to a sunburn.
Skin symptoms can begin within weeks or months of starting immunotherapy and may last even after treatment ends.
Existing skin conditions like eczema or psoriasis may also flare up during immunotherapy, says Alter.
Tips to Manage Skin Reactions
Alter recommends the following tips for managing skin reactions.
- Use gentle, fragrance-free soaps and moisturizers.
- Shower with lukewarm water, instead of hot, and pat your skin dry after.
- Apply a thick, unscented cream or lotion often, especially after showering.
- Avoid direct sunlight, wear protective clothing, and use a broad-spectrum sunscreen with an SPF of 30 or higher daily.
- Apply cool, moist compresses to itchy areas for relief.
- Talk to your care team about topical steroid creams or oral medications for more stubborn or severe reactions.
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